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Marja Jäättelä Selected Research

HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)

5/2014Human heat shock protein 70 (Hsp70) as a peripheral membrane protein.
3/2007Lens epithelium-derived growth factor is an Hsp70-2 regulated guardian of lysosomal stability in human cancer.
3/2005Members of the heat-shock protein 70 family promote cancer cell growth by distinct mechanisms.
12/2004Heat shock protein 70 promotes cancer cell viability by safeguarding lysosomal integrity.
9/2004[Heat shock protein 70: an important survival factor for cancer cells].
8/2004Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization.
2/2004Lack of neuroprotection by heat shock protein 70 overexpression in a mouse model of global cerebral ischemia.
9/2003Cell death induced by down-regulation of heat shock protein 70 in lung cancer cell lines is p53-independent and does not require DNA cleavage.
4/2003Overexpression of heat shock protein 70 in R6/2 Huntington's disease mice has only modest effects on disease progression.
12/2002Eradication of glioblastoma, and breast and colon carcinoma xenografts by Hsp70 depletion.

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Marja Jäättelä Research Topics

Disease

61Neoplasms (Cancer)
08/2021 - 01/2002
22Breast Neoplasms (Breast Cancer)
08/2021 - 08/2002
4Carcinoma (Carcinomatosis)
03/2016 - 12/2004
3Osteosarcoma (Osteogenic Sarcoma)
01/2022 - 09/2002
3Ovarian Neoplasms (Ovarian Cancer)
08/2021 - 02/2019
3Starvation
10/2020 - 07/2007
3Niemann-Pick Diseases (Niemann Pick Disease)
01/2016 - 01/2010
2Ataxia Telangiectasia (Louis Bar Syndrome)
10/2020 - 11/2011
2Leukemia
01/2020 - 09/2002
2Carcinogenesis
02/2019 - 11/2005
2Neurodegenerative Diseases (Neurodegenerative Disease)
01/2019 - 04/2003
2Prostatic Neoplasms (Prostate Cancer)
07/2016 - 10/2013
2Necrosis
11/2015 - 03/2009
2Neoplasm Metastasis (Metastasis)
04/2005 - 05/2002
1Ovarian Epithelial Carcinoma
02/2019

Drug/Important Bio-Agent (IBA)

21Proteins (Proteins, Gene)FDA Link
10/2020 - 12/2002
10HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)IBA
05/2014 - 12/2002
10CaspasesIBA
08/2009 - 01/2002
9CathepsinsIBA
02/2018 - 12/2004
7Lu 28-179 (Siramesine)IBA
01/2020 - 10/2005
7Pharmaceutical PreparationsIBA
01/2020 - 10/2005
6AcidsIBA
08/2020 - 06/2010
5Phosphotransferases (Kinase)IBA
10/2020 - 01/2007
4Mechanistic Target of Rapamycin Complex 1IBA
10/2020 - 07/2007
4Carrier Proteins (Binding Protein)IBA
10/2020 - 03/2016
4LipidsIBA
01/2020 - 01/2010
4Histamine Antagonists (Antihistamines)IBA
01/2020 - 07/2016
4Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA
10/2013 - 01/2010
4LigandsIBA
03/2009 - 10/2005
4sigma-2 receptorIBA
10/2008 - 10/2005
3Small Interfering RNA (siRNA)IBA
10/2020 - 08/2011
3DNA (Deoxyribonucleic Acid)IBA
10/2020 - 03/2016
3lens epithelium-derived growth factorIBA
03/2016 - 03/2007
3Cysteine (L-Cysteine)FDA Link
03/2012 - 12/2004
2ProteomeIBA
01/2022 - 01/2009
2Protein Kinases (Protein Kinase)IBA
10/2020 - 03/2012
2AMP-Activated Protein KinasesIBA
10/2020 - 07/2007
2Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA
10/2020 - 03/2012
2Sirolimus (Rapamycin)FDA Link
10/2020 - 03/2012
2Protons (Proton)IBA
08/2020 - 01/2020
2Lactic Acid (Lactate)FDA LinkGeneric
08/2020 - 01/2020
2MicroRNAs (MicroRNA)IBA
02/2018 - 09/2011
2ZincIBA
02/2018 - 03/2012
2Transcription Factors (Transcription Factor)IBA
02/2018 - 01/2016
2SphingomyelinsIBA
01/2016 - 09/2013
2Peptide Hydrolases (Proteases)FDA Link
11/2015 - 04/2005
2Protein Phosphatase 2 (Protein Phosphatase 2A)IBA
07/2014 - 03/2014
2Amino AcidsFDA Link
03/2012 - 12/2008
2Vitamin DFDA LinkGeneric
07/2010 - 08/2002
2Antineoplastic Agents (Antineoplastics)IBA
03/2007 - 09/2002
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
12/2004 - 11/2003
2Complementary DNA (cDNA)IBA
12/2004 - 12/2002
1pertuzumabIBA
08/2021
1Trastuzumab (Herceptin)FDA Link
08/2021
1Podophyllotoxin (Condylox)FDA LinkGeneric
08/2021
1Auranofin (Ridaura)FDA Link
08/2021
1Quinacrine (Mepacrine)IBA
08/2021
1Thiostrepton (Gargon)IBA
08/2021
1Monensin (Coban)IBA
08/2021
1ColchicineFDA LinkGeneric
08/2021
1NiclosamideFDA Link
08/2021
1Lapatinib (GW572016)FDA Link
08/2021
1Autophagy-Related Protein-1 HomologIBA
10/2020
1Beclin-1IBA
10/2020
1Phosphatidylinositols (Phosphatidylinositol)IBA
10/2020
1Renilla LuciferasesIBA
10/2020
1Bovine Serum AlbuminIBA
10/2020
1AICA ribonucleotide (ZMP)IBA
10/2020
1Ribosomal Protein S6 Kinases (S6 Kinase)IBA
10/2020
1DNA-Activated Protein KinaseIBA
10/2020
1Minichromosome Maintenance Complex Component 7IBA
10/2020
1Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA
10/2020
1Histones (Histone)IBA
10/2020
1Phosphates (Orthophosphate)IBA
10/2020
1Alanine (L-Alanine)FDA Link
10/2020
1Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
10/2020
1MAP Kinase Kinase Kinases (MAP Kinase Kinase Kinase)IBA
10/2020
1Glyceraldehyde-3-Phosphate Dehydrogenases (GAPD)IBA
10/2020
1Glutathione Transferase (Glutathione S-Transferase)IBA
10/2020
1Adenosine Monophosphate (AMP)IBA
10/2020
1Fluorouracil (Carac)FDA LinkGeneric
10/2020
1RibonucleotidesIBA
10/2020
1Cyclin-Dependent Kinases (cdk Proteins)IBA
10/2020
1Acetyl-CoA CarboxylaseIBA
10/2020
1Red Fluorescent ProteinIBA
10/2020
1Phosphatidylinositol 4,5-Diphosphate (Phosphatidylinositol 4,5 Diphosphate)IBA
10/2020
1lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA
10/2020
1Cystathionine beta-Synthase (Serine Sulfhydrase)IBA
10/2020
1enhanced green fluorescent proteinIBA
10/2020
1Hanks Balanced Salt SolutionIBA
10/2020
1Ion Pumps (Ion Pump)IBA
08/2020
1SolutionsIBA
01/2020
1Glucose (Dextrose)FDA LinkGeneric
01/2020
1Glycerophospholipids (Phosphoglycerides)IBA
01/2020
1Histamine (Histamine Dihydrochloride)FDA Link
02/2019
1ORALIT (ORS)IBA
02/2019
1CationsIBA
01/2019

Therapy/Procedure

25Therapeutics
08/2021 - 05/2002
6Drug Therapy (Chemotherapy)
01/2019 - 11/2005
1Aftercare (After-Treatment)
01/2020